Insulin stimulates the L-type Ca2+ current in rat cardiac myocytes
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چکیده
منابع مشابه
RhoA GTPase regulates L-type Ca2+ currents in cardiac myocytes.
Regulation of ionic channels plays a pivotal role in controlling cardiac function. Here we show that the Rho family of small G proteins regulates L-type Ca2+ currents in ventricular cardiomyocytes. Ventricular myocytes isolated from transgenic (TG) mice that overexpress the specific GDP dissociation inhibitor Rho GDI-alpha exhibited significantly decreased basal L-type Ca2+ current density (app...
متن کاملStimulation of L-type Ca2+ current in human atrial myocytes by insulin.
OBJECTIVE The L-type calcium current (ICa,L) in isolated human atrial myocytes was investigated as a possible target of insulin in the regulation of cardiac function. METHODS Atrial myocytes were obtained from patients undergoing cardiac surgery. Using the whole-cell configuration of the patch-clamp technique, we investigated the stimulation of ICa,L by insulin in single human atrial myocytes...
متن کاملL-type Ca2+ current in fish cardiac myocytes: effects of thermal acclimation and beta-adrenergic stimulation.
A patch-clamp analysis of L-type Ca2+ current in ventricular myocytes of cold- and warm-acclimated rainbow trout (Oncorhynchus mykiss) and crucian carp (Carassius carassius) hearts was performed. Trout were acclimated at 4 and 17 degrees C and carp at 4 and 24 degrees C for a minimum of 4 weeks. Ventricular myocytes were isolated by enzymatic dissociation using collagenase and trypsin. Marked s...
متن کاملInhibition of L-type Ca2+ current by ginsenoside Rd in rat ventricular myocytes
BACKGROUND Ginsenoside Rd (GSRd), one of the most abundant ingredients of Panax ginseng, protects the heart via multiple mechanisms including the inhibition of Ca(2+) influx. We intended to explore the effects of GSRd on L-type Ca(2+) current (I Ca,L) and define the mechanism of the suppression of I Ca,L by GSRd. METHODS Perforated-patch recording and whole-cell voltage clamp techniques were ...
متن کاملAnandamide Reduces Intracellular Ca2+ Concentration through Suppression of Na+/Ca2+ Exchanger Current in Rat Cardiac Myocytes
PURPOSE Anandamide, one of the endocannabinoids, has been reported to exhibit cardioprotective properties, particularly in its ability to limit the damage produced by ischemia reperfusion injury. However, the mechanisms underlying the effect are not well known. This study is to investigate whether anandamide alter Na(+)/Ca(2+) exchanger and the intracellular free Ca(2+) concentration ([Ca(2+)]i...
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ژورنال
عنوان ژورنال: Cardiovascular Research
سال: 1999
ISSN: 0008-6363
DOI: 10.1016/s0008-6363(98)00307-1